Guías y taxonomía
[1] Becker CM, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009.
PubMed 35350465 DOI 10.1093/hropen/hoac009 Texto completo gratis (PMC)
[2] Teede HJ, et al. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Hum Reprod. 2023;38(9):1655-1679.
PubMed 37580037 DOI 10.1093/humrep/dead156 Texto completo gratis (PMC)
[3] Zheng J, et al. A taxonomic note on the genus Lactobacillus: description of 23 novel genera... Int J Syst Evol Microbiol. 2020;70(4):2782-2858.
Microbioma, eje intestino-ginecológico y estroboloma
[4] Colonetti T, et al. Gut and vaginal microbiota in the endometriosis: systematic review and meta-analysis. Biomed Res Int. 2023;2023:2675966.
PubMed 38601772 DOI 10.1155/2023/2675966 Texto completo gratis (PMC)
[5] Kalopedis EA, et al. Leveraging the role of the microbiome in endometriosis: novel non-invasive and therapeutic approaches. Front Immunol. 2025;16:1631522.
PubMed 41035652 DOI 10.3389/fimmu.2025.1631522 Texto completo gratis (PMC)
[6] Leonardi M, et al. Endometriosis and the microbiome: a systematic review. BJOG. 2020;127(2):239-249.
PubMed 31454452 DOI 10.1111/1471-0528.15916
[7] Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: physiological and clinical implications. Maturitas. 2017;103:45-53.
PubMed 28778332 DOI 10.1016/j.maturitas.2017.06.025
[8] Plottel CS, Blaser MJ. Microbiome and malignancy. Cell Host Microbe. 2011;10(4):324-335.
PubMed 22018233 DOI 10.1016/j.chom.2011.10.003 Texto completo gratis (PMC)
[9] Liu X, et al. Gut microbiota as a key regulator in endometriosis: mechanisms, therapeutic opportunities, and future perspectives. Front Cell Infect Microbiol. 2025.
PubMed 41693858 DOI 10.3389/fcimb.2025.1730739 Texto completo gratis (PMC)
[10] Chadchan SB, et al. Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis. Life Sci Alliance. 2021;4(12):e202101224.
PubMed 34593556 DOI 10.26508/lsa.202101224 Texto completo gratis (PMC)
Lactobacillus acidophilus
[11] Shalev E, et al. Ingestion of yogurt containing Lactobacillus acidophilus compared with pasteurized yogurt as prophylaxis for recurrent candidal vaginitis and bacterial vaginosis. Arch Fam Med. 1996;5(10):593-596.
PubMed 8930233 DOI 10.1001/archfami.5.10.593
[12] Donders GG, et al. Effect of lyophilized lactobacilli and 0.03 mg estriol (Gynoflor) on vaginitis and vaginosis with disrupted vaginal microflora: a multicenter, randomized, single-blind, active-controlled pilot study. Gynecol Obstet Invest. 2010;70(4):264-272.
PubMed 21051846 DOI 10.1159/000314016
[13] Russo R, Karadja E, De Seta F. Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. Benef Microbes. 2019;10(1):19-26.
PubMed 30525953 DOI 10.3920/BM2018.0075
[14] Khodaverdi S, et al. Beneficial effects of oral Lactobacillus on pain severity in women suffering from endometriosis: a pilot placebo-controlled randomized clinical trial. Int J Fertil Steril. 2019;13(3):178-183.
PubMed 31310070 DOI 10.22074/ijfs.2019.5584 Texto completo gratis (PMC)
Nota: Mezcla: L. acidophilus, L. plantarum, L. fermentum, L. gasseri (no OLL2809).
Streptococcus salivarius
[15] Wescombe PA, et al. Developing oral probiotics from Streptococcus salivarius. Future Microbiol. 2012;7(12):1355-1371.
PubMed 23231486 DOI 10.2217/fmb.12.113
Nota: CORREGIDA: la cita anterior (Antonie van Leeuwenhoek 2006) no correspondía.
[16] Burton JP, et al. A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J Appl Microbiol. 2006;100(4):754-764.
PubMed 16553730 DOI 10.1111/j.1365-2672.2006.02837.x
Lactobacillus casei / VPH
[17] Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study. Am J Obstet Gynecol. 2010;203(2):120.e1-6.
PubMed 20659602 DOI 10.1016/j.ajog.2010.05.023
[18] Verhoeven V, et al. Probiotics enhance the clearance of human papillomavirus-related cervical lesions: a prospective controlled pilot study. Eur J Cancer Prev. 2013;22(1):46-51.
PubMed 22706167 DOI 10.1097/CEJ.0b013e328355ed23
[19] Susetiati DA, et al. Effectiveness of Lactobacillus therapy in women with cervical human papillomavirus infection: a systematic review and meta-analysis. J Int Med Res. 2025;53(9).
PubMed 40762255 DOI 10.1177/03000605251363006 Texto completo gratis (PMC)
[20] Abdolalipour E, et al. Synergistic therapeutic effects of probiotic Lactobacillus casei TD-2 consumption on GM-CSF-induced immune responses in a murine model of cervical cancer. Nutr Cancer. 2022;74(1):372-382.
PubMed 33356596 DOI 10.1080/01635581.2020.1865419
[21] Paniágua AL, et al. Inhibitory effects of Lactobacillus casei Shirota against both Candida auris and Candida spp. isolates that cause vulvovaginal candidiasis. BMC Complement Med Ther. 2021;21:237.
PubMed 34556109 DOI 10.1186/s12906-021-03405-z Texto completo gratis (PMC)
Lactobacillus plantarum
[22] De Seta F, et al. Lactobacillus plantarum P17630 for preventing Candida vaginitis recurrence: a retrospective comparative study. Eur J Obstet Gynecol Reprod Biol. 2014;182:136-139.
PubMed 25305660 DOI 10.1016/j.ejogrb.2014.09.018
[23] Vladareanu R, et al. New evidence on oral L. plantarum P17630 product in women with history of recurrent vulvovaginal candidiasis (RVVC): a randomized double-blind placebo-controlled study. Eur Rev Med Pharmacol Sci. 2018;22(1):262-267.
PubMed 29364495 DOI 10.26355/eurrev_201801_14128
[24] Vahedpoor Z, et al. Adjunctive probiotic therapy enhances metronidazole efficacy in bacterial vaginitis: a clinical trial on Iranian women. GMS Hyg Infect Control. 2026.
PubMed 42483470 DOI 10.3205/dgkh000651 Texto completo gratis (PMC)
[25] Nisaa AA, et al. Randomized, double-blind, placebo-controlled trial of the probiotic Lactiplantibacillus plantarum Probio87 for... Mol Nutr Food Res. 2026.
PubMed 42441416 DOI 10.1002/mnfr.70535 Texto completo gratis (PMC)
[26] Strus M, et al. Studies on the effects of probiotic Lactobacillus mixture given orally on vaginal and rectal colonization and on parameters of vaginal health in women with intermediate vaginal flora. Eur J Obstet Gynecol Reprod Biol. 2012;163(2):210-215.
Bifidobacterium
[27] van de Wijgert JHHM, et al. Intermittent lactobacilli-containing vaginal probiotic or metronidazole use to prevent bacterial vaginosis recurrence: a pilot study incorporating microscopy and sequencing. Sci Rep. 2020;10:3884.
PubMed 32127550 DOI 10.1038/s41598-020-60671-6 Texto completo gratis (PMC)
[28] Afifirad R, et al. Effects of pro/prebiotics alone over pro/prebiotics combined with conventional antibiotic therapy to treat bacterial vaginosis: a review. Int J Clin Pract. 2022;2022:4774783.
PubMed 35685517 DOI 10.1155/2022/4774783 Texto completo gratis (PMC)
L. reuteri + L. rhamnosus (GR-1 / RC-14) y seguridad
[29] Petricevic L, et al. Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2008;141(1):54-57.
PubMed 18701205 DOI 10.1016/j.ejogrb.2008.06.003
[30] Martinez RC, et al. Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), L. rhamnosus GR-1, and L. reuteri RC-14: a randomized, double-blind, placebo-controlled trial. Can J Microbiol. 2009;55(2):133-138.
PubMed 19295645 DOI 10.1139/w08-102
[31] Martinez RC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic L. rhamnosus GR-1 and L. reuteri RC-14. Lett Appl Microbiol. 2009;48(3):269-274.
PubMed 19187507 DOI 10.1111/j.1472-765X.2008.02477.x
[32] Hummelen R, et al. Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV. Int J Gynaecol Obstet. 2010;111(3):245-248.
PubMed 20801446 DOI 10.1016/j.ijgo.2010.07.008
[33] Gille C, et al. Effect of probiotics on vaginal health in pregnancy. EFFPRO, a randomized controlled trial. Am J Obstet Gynecol. 2016;215(5):608.e1-608.e7.
PubMed 27342046 DOI 10.1016/j.ajog.2016.06.021
[34] Krauss-Silva L, et al. A randomised controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with bacterial vaginosis: preliminary results. Trials. 2011;12:239.
PubMed 22059409 DOI 10.1186/1745-6215-12-239 Texto completo gratis (PMC)
[35] Huang H, Song L, Zhao W. Effects of probiotics for the treatment of bacterial vaginosis in adult women: a meta-analysis of randomized clinical trials. Arch Gynecol Obstet. 2014;289(6):1225-1234.
PubMed 24318276 DOI 10.1007/s00404-013-3117-0
[36] Morelli L, et al. Utilization of the intestinal tract as a delivery system for urogenital probiotics. J Clin Gastroenterol. 2004;38(6 Suppl):S107-S110.
PubMed 15220672 DOI 10.1097/01.mcg.0000128938.32835.98
[37] Salminen MK, et al. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG. Clin Infect Dis. 2004;38(1):62-69.
Bifidobacterium lactis
[38] Jungersen M, et al. The science behind the probiotic strain Bifidobacterium animalis subsp. lactis BB-12. Microorganisms. 2014;2(2):92-110.
PubMed 27682233 DOI 10.3390/microorganisms2020092 Texto completo gratis (PMC)
[39] ELIMINADA: 'Marschal M, et al. Lactobacilos orales y arándano en VB, Geburtshilfe Frauenheilkd 2012' no se encontró en PubMed.
Nota: No usar. Hay que retirar del dossier la afirmación sobre B. lactis BB-12 + PAC en vaginosis bacteriana.
Selenio
[40] Jamilian M, et al. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2015;82(6):885-891.
PubMed 25510442 DOI 10.1111/cen.12699
[41] Mier-Cabrera J, et al. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reprod Biol Endocrinol. 2009;7:54.
PubMed 19476631 DOI 10.1186/1477-7827-7-54 Texto completo gratis (PMC)
[42] EFSA NDA Panel. Scientific Opinion on Dietary Reference Values for selenium. EFSA J. 2014;12(10):3846.
PubMed 42087966 DOI 10.2903/j.efsa.2014.3846 Texto completo gratis (PMC)
Cúrcuma
[43] Jamilian M, et al. Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Nutr ESPEN. 2020;36:128-133.
PubMed 32220355 DOI 10.1016/j.clnesp.2020.01.005
[44] Heshmati J, et al. Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. Phytomedicine. 2021;80:153395.
PubMed 33137599 DOI 10.1016/j.phymed.2020.153395
[45] Khayat S, et al. Curcumin attenuates severity of premenstrual syndrome symptoms: a randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2015;23(3):318-324.
Inulina / prebióticos
[46] Roberfroid M, et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010;104 Suppl 2:S1-S63.
PubMed 20920376 DOI 10.1017/S0007114510003363
[47] Gibson GR, et al. Expert consensus document: The ISAPP consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502.
PubMed 28611480 DOI 10.1038/nrgastro.2017.75
[48] Gholizadeh Shamasbi S, et al. The effect of resistant dextrin as a prebiotic on metabolic parameters and androgen level in women with polycystic ovarian syndrome: a randomized, triple-blind, controlled, clinical trial. Eur J Nutr. 2019;58(2):629-640.
Excipientes
[49] Rowe RC, Sheskey PJ, Quinn ME (eds). Handbook of Pharmaceutical Excipients. 6th ed. London: Pharmaceutical Press; 2009.